Anesthesia-Induced Neuronal Apoptosis in the Developing Retina
نویسندگان
چکیده
منابع مشابه
Neuronal coupling in the developing mammalian retina.
During the first 3 weeks of postnatal development in the ferret retina, cells in the ganglion cell layer spontaneously generate waves of electrical activity that travel across the retina in the absence of mature photoreceptors (Meister et al., 1991; Wong et al., 1993). Since few chemical synapses are present at the earliest stages when waves are present, we have explored whether gap junctions c...
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1 describe how isoflurane produces apoptosis in the retina in 7-day-old mouse pups. They found that exposure to 2% isoflurane for 1 hour resulted in apoptosis in cells in the inner nuclear layer of the retina, which by double-label immunostaining appeared to be amacrine and bipolar cells. Increasingly, anesthesiologists have become concerned about the risks of exposing the immature brain to ane...
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Introduction: Lead toxicity induces retinal cell apoptosis. Vitamin C and garlic may decrease lead-induced apoptosis. This study was undertaken to investigate vitamin C and garlic protective effects on lead-induced apoptosis in eye retina. Methods: Pregnant Wistar rats (n = 72) were divided randomly into 9 groups: (L) treated rats with lead acetate in drinking water and (L+AA) with leaded water...
متن کاملAnesthesia-induced neuronal apoptosis during synaptogenesis: a review of the literature.
Anesthesia is generally accepted as safe in most adult populations; however, in pediatric patients questions exist regarding the potential for long-term detrimental effects. Various anesthetic agents are associated with neuronal degeneration when administered to neonatal animals. The mechanism of damage is thought to be via accelerated apoptosis, a normally beneficial process in the maintenance...
متن کاملXenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain.
BACKGROUND Anesthetics, including isoflurane and nitrous oxide, an antagonist of the N-methyl-D-aspartate subtype of the glutamate receptor, have been demonstrated to induce apoptotic neurodegeneration when administered during neurodevelopment. Xenon, also an N-methyl-D-aspartate antagonist, not only lacks the characteristic toxicity produced by other N-methyl-D-aspartate antagonists, but also ...
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ژورنال
عنوان ژورنال: Anesthesia & Analgesia
سال: 2015
ISSN: 0003-2999
DOI: 10.1213/ane.0000000000000714